Incorporation of flexible objectives and time-linked simulation with flux balance analysis
نویسندگان
چکیده
منابع مشابه
Incorporation of flexible objectives and time-linked simulation with flux balance analysis.
We present two modifications of the flux balance analysis (FBA) metabolic modeling framework which relax implicit assumptions of the biomass reaction. Our flexible flux balance analysis (flexFBA) objective removes the fixed proportion between reactants, and can therefore produce a subset of biomass reactants. Our time-linked flux balance analysis (tFBA) simulation removes the fixed proportion b...
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Flux balance analysis (FBA) is an in silico metabolic analysis technique that has been used to identify potential drug targets in pathogens (disease-causing organisms) by determining essential biochemical reactions in these organisms [1]. To do this, previous studies have generally focused on completely removing each reaction in turn and checking if the pathogens can still survive, without quan...
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Biology is going through a paradigm shift from reductionist to holistic, systems-based approaches. The complete genome sequence for a number of organisms is available and the analysis of genome sequence data is proving very useful. Thus, genome sequencing projects and bioinformatic analyses are leading to a complete 'parts catalog' of the molecular components in many organisms. The next challen...
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In this paper, a new structure of axial flux switched reluctance motors (AFSRMs) is proposed. Different combinations of rotors and stators affect motor torque and its performance. In this regard, changing the stator structure of the AFSRM leads to better results for torque and magnetic flux. The advantages of the proposed structure are short flux path, segmental rotor with improved flux density...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2014
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2013.12.009